💡 Uses & Benefits

• Rheumatoid arthritis (RA): Ideal for adult patients with moderate to severely active RA who haven't responded adequately to TNF antagonist therapies citeturn0search0turn0search1.

• Emergency COVID-19 use: Authorized (EUA/FDA) for hospitalized COVID-19 patients in need of oxygen, often used alongside Remdesivir citeturn0search0turn0search3.

• Selective JAK1/JAK2 inhibition: Reduces inflammation by preventing STAT phosphorylation, modulating immune and cytokine response citeturn0search0turn0search1.

📋 Product Specifications

⚠️ Safety & Precautions

• Infection risk: Monitor for serious infections (e.g. TB, herpes zoster); if infection occurs, interrupt treatment citeturn0search3turn0search8.

• Hematologic issues: Avoid in patients with low hemoglobin (< 8 g/dL), neutrophils (< 1000 cells/mm³), or lymphocytes (< 500 cells/mm³) citeturn0search0turn0search1.

• Thrombosis & GI risk: Use caution in patients with thrombotic risk or GI perforation history citeturn0search3turn0search8.

• Lab monitoring: Baseline and periodic checks—CBC, LFTs, lipids citeturn0search0turn0search3.

• Renal dosing: For eGFR 30–60 mL/min, reduce to 1 mg daily; not recommended for eGFR < 30 mL/min citeturn0search0turn0search3turn0search1.

• Pregnancy & breastfeeding: Contraindicated during pregnancy and likely not safe in breastfeeding citeturn0search5turn0search3.

• Drug interactions: Avoid strong OAT3 inhibitors (e.g. probenecid) and live vaccines citeturn0search1turn0search3.

📌 Quick Overview

• Therapeutic class: JAK1/JAK2 inhibitor for RA & COVID-19

• Convenience: Once-daily oral tablet

• Local brand: Manufactured in Bangladesh by Square Pharmaceuticals

• Ideal for: Rheumatoid arthritis patients who don't respond to TNF blockers; hospitalized COVID-19 patients under EUA

• Price: Affordable (~৳25/tablet), prescription required